Cell Cycle Lessons

Module 7 – Microbiology and Disease

Links to Teaching Resources

Jump to: Microbes, Practical Microbiology, Industrial Microbiology, Antibiotics, Disease, Immune System, Vaccina= tion

      Countdown= Timer from Echalk. Very useful!

Bact= eria

Bacteria Stru= cture

      Bac= teria powerpoint

      Bacteria structure from Starr. Good.

      3D animation of bacteria motility (local)

      How bacteria swim from cells Alive

      Rhodospi= rilum bacteria from Leicester (local). Vid= eo of motility, but not very exciting.

      Todar’s Online textbook of bacteriology. Good for background information.

Bacteria Reproduction

      Bacteria fission from Starr. Good, just like notes.

      Bacte= ria fission from ASM. Bit simple.

Viruses

Virus Structu= re

      Virus powerp= oint (NCM)

      Coronavirus movie (local). Computer animation of viruses. Doesn’t do anything, but fun.

      Virus Imag= es from the UK Clinical Virology Network

      Virus Ultrastru= cture by Linda Stannard

      Herpes simplex pages from Edward Wagner. Very nice animations of structure and replication, thought not actually needed.

      Icosahed= ron animation (local). Just that – for students who never made one in= Y7 maths.

      Virus classification table from Iowa State (local), show= ing structures and diseases caused.

      HIV structure from Dan Stowell

      Exploding reovirus showing layers (local)

      Coiled RNA in a virus animation (local)

      All the Virology on the W= WW. Big site for background information/research.

      The Big Pictu= re Book of Viruses by David Sander

      Influenza v= irus image from 3dscience.com

Virus Reproduction

      Virus infecting a cell from ASM. Simple overview, but not technical. Quite go= od introduction.

      Viral replication from Starr showing lytic and lysogenic pathways. Nice summa= ry of the two pathways, but not much detail.

      Viral replication from Mader showing lytic and lysogenic pathways.

      Replication of Herpes simplex virus from Sumanas. Not needed.

      Enveloped virus entry and release from a cell from Madder.

      HIV replication from Mader. Good animation of a “general” retrovirus. Show first.

      HIV replication from Mader. Detailed but superb animation of HIV replicatio= n. Spot on! Also from Raven and McKinley

      HIV infection from Leicester (local). More “realistic” animation. Worth showing.

      HIV lifecycle from Sumanas. Detailed, but not as good as Mader.

      H= IV lifecycle. (local). OK, but not as good as Mader.

      HIV lifecycle from Roche. Step-through animation, with focus on how antivir= al drugs work. OK, but not really needed.

      Viral infectio= n from HHMI Biointeractive – go to bottom of page. Nice, but not as nic= e as others.

      Viral Reproduction from Thames V= alley Ontario. Very simple, and n= ot as good as others.

Microbes

General Information/Sites on microbes

      Microbial World from = Edinburgh

      Mov= ie of intracellular parasites

      Microbiology On-line from SGM

      Pr= okaryotes, Eukaryotes and Viruses from Arizona Biology Project

      Micro*scope from MBL Woods Hole

      Quiz on microbes from Cells Alive

      Microb= es info

      Careers in microbiology Powerpoint from SGM

      Careers in microbiology leaflet from SGM (pdf file)

      Introduction to microbiology Powerpoint from SGM

      M= icrobeLibrary from ASM. Some useful free images, etc.

      MicrobeWorld resources

      Microbe wiki for reverence

Prac= tical Microbiology

Techniques

      Gram stain animation. From Microbelibrary.org. Very good step-by-step animat= ion showing how it works.

      Streak plates from Sumanas. Very nice.

      Laboratory aseptic techniques movie (local). Not much here (use MMU’s DVD instead)
      Microbiology lab exerci= ses from Judy Earl. Nice website showing many common techniques.

      Laboratory technique= s from University of Texas Houston. N= ice website showing many common techniques.

      Practical microbiology handbook from Manchester Metropolitan University (local pdf file). Good for reference.

      Micro-autoradiogram from Sumanas, showing uptake of radiolabelled nucleotides. Interesting, but= not relevant.

      Aseptic techni= que presentation from ASM (local)

      How to deal with spill= s from ASM (local)

      The Winogradsky column from Sumanas

Growth Curves

      Bacteria growth (local) showing bacilli doubling to form colonies under the microscope. Also with growth curve superimposed.

      Bacteria Cam from Cells Alive showing growth in real time, updated every minute. Could be good if left for a whole lesson. Also bacteria growth images fro= m Cells Alive, but not as good as local video above.

      Food pathogens from Mader. Covers growth curves, factors affecting growth ra= te, and food spoilage

      Microbes and food spoilage from Mader. Does optimum temperature of different bacteria. Rather nice.

      Bacteria spore formation from Mader. Not needed, but very interesting.

      Inhibi= ting the growth of bacteria from WebLab. Simulation of an inhibition experim= ent, but a bit silly.

Other

Indu= strial Microbiology

      Lab fermenters movie 1 and 2 (local). Quite good for showing parts.

      Genentech Tour from DNAi (choose Manipulation-Produc= tion-Putting it together). Good idea of industrial-scale fermenters.

      Industrial fermenters movie (local). Very short.

      Brewing movies 1, 2 (showing fermente= rs) and 3 (local)

      Mould movie (local)

      Yeast b= ubbling movie (local) and Dough rising movie

      Sewage works movie (local)

      Biotimes – E-magazine from Novozymes

      Enzymes in biotechnology from ActiveScience

      T= he discovery of penicillin from Nobelprize

      Belhaven Brewery<= /a> virtual tour

Anti= biotics and Resistance

Mechanism

      How penicillin kills bacteria from Cells Alive (also local)

      Antibiotics attack from HHMI Biointeractive

Production

      Screening for antibiotic production from Suamanas

Resistance

      Bacteria= l Conjugation (local) from Alberts ECB. Starts with electron micrograph. Good.

      Bacterial Conj= ugation from HHMI Biointeractive. Go to bottom of page. Bit simple.

      Bacterial Conjugation from Mader. Detailed and very good. Also a more complicated example about the transfer of chromosomal DNA (not needed).=

      Bacterial Transduction from Mader. Very good. Also a different version (not needed).

      Bacterial Transformation from Mader. Complex but good.

      The = rise in antibiotic resistance from Sumanas

Dise= ase

Salmonellosis=

      Sal= monellosis from CDC

Typhoid<= /o:p>

      Treatment for HIV from Raven

Influenza

      Flu = from CDC

HIV/AIDS=

      Treatment for HIV from Raven

      HIV infection mechanism from Madder showing in detail how HIV infects macrophages and eventually causes AIDS. Detailed, but good.

      HIV life cycle f= rom Nova. Brilliant.

      HIV.AIDS= from CDC

General Disease

      Disease Organisms Information Sheets from Michael McDarby. Interesting list of diseases and their microbes.

      Cen= tre for Disease Control and Prevention. Lots of stuff.

      Helicobacter pylori from Cells Alive. Interesting story.

      Tuberculosis from Nobelprize. Re-live Robert Koch’s discovery of the TB bacterium.= Fun, but not relevant.

      Food Safety from Institute= of Food Research. Information sheets.

      H= erpes infection. Boring.

      I= nfectious Disease from HHMI Biointeractive. Simple animations of Ecoli and Salmonella. Not good.

      Streptococci killing white blood cells from Cells Alive

      Action of bacterial toxins from Sumanas. Not needed, but nice.

Immu= ne System

The immune sy= stem

      Immune system from ADAM

      Different types of white blood cells from John Wiley

      Immune system lectures from Balti= more college. Good background for teachers; not for students.

      Immune system slideshow from National cancer Institute. Quite nice “lecture”, but too advanced for students.

      Immune system powerpoint from Pearson. Advanced, but could use some slides.

      Immunology Animations from Janeway. Choose 5^th edition, which doesnR= 17;t have a watermark. Animations are very detailed, but not as good as the ones above.

      Ce= lls and Organs of the Immune system from Lifewire. Just that. OK, but not v= ery exciting.

      Microbes and Disease powerpoint from SGM. Low level – better for KS3/4.

      The immune system from Nobelprize

      Label the immune system from Mader

      Immunity lectures from Gary Kaiser

      ADAM = from University of Maryland

      Immunology from HHMI Biointeractive

      Quiz on the immune system from Cells Alive

      Diaghram of the lymphatic system from John Wiley

      Immune system quiz from Murray Jensen

      White blood = cells from blobs.org

      Lymphocytes<= /a> from blobs.org

Normal flora

      Normal flora 1 and 2 (local) from ASM. Brief but very nice!

The inflamatory response

      Inflamatory response animation from Sumanas. Good introduction.

      Histamine inflammatory response from MUhealth, or local. Similar to Sumanas, but not as good.

      Phagocytes and inflamatory response from ASM (local). Similar to Sumanas, but simp= ler.

      Inflammation from Starr. 5-step process. OK

      = Leukocytes and inflamatory response from Alberts ECB (local). Animation and real movie. Very nice.

      = Lymphocyte homing movie from Alberts ECB (local). Actual movie of lymphocytes leav= ing capillary and migrating to wound. Nice.

      Wound healing from Alberts (local). Animation and real movie. Nice.

      Plat= elet formation from Alberts ECB (local)

      Platelets and inflamatory response 1 medical animation (local). Animation of platelets collecting at wound. No narration.

      Platele= ts and inflamatory response 2 medical animation (local). Very detailed. Hi= gh quality but not relevant.

      Complement protein action from Starr

      Complement from blobs.org

      Ouch! The inflammatory response from Cells Alive

      Blood clot mechanism from McGraw-Hill. Very complicated, but nice.

Pagocytosis

      Phagocytosis movie from Alberts ECB (local). Red yeast cells engulfed by green slime moulds. Nice.

      Neutrophyll chasing movie from Alberts ECB (local). Movie of neutrophyll chasing and engulfing a bacterium. Brilliant.

      Neutrophyll chemotaxis movie from Alberts ECB (local). Movie of neutrophylls respon= ding to experimental chemical.

      Neutro= phyll stampede from Cells Alive (local)

      Phog= ocytosis animation and movie from Ce= lls Alive (local)

      Phagocytosis movie from Utah State. Very low res= .

      Antigen processing (local)

Antibodies

      An= tibody synthesis from Lifewire. Details of alternative gene splicing. Quite complicated.

      Monoclonal antibodies from Raven. Not really relevant, but includes details of B c= ells and antibodies.

      = Engineering antibodies from Schoolscience

      Antibody structrure from Alberts ECB (local)

      Antibodies from blobs.org

Specific Immune Response

      The immune response from McKinley. Good

      Humoral immune response from Raven. Very good.

      Ce= llular immune response from Lifewire. Good.

      Hu= moral immune response from Lifewire. Good.

      C= ellular immune response (local). Detailed but very good.

      Hu= moral Immune response (local). Detailed but very good.

      Killer T-cells From Alberts (local). Short movie showing a real NK cell attack= ing a fibroblast.

      Perforin killing a bacterial cell (local). Quick, but quite nice.

      Antibody-mediated response from Starr

      Cell-mediated response from Starr

      Clonal Selection from Starr

      Immune memory from Starr

      Immune response from Starr

      Acquired Imm= unity from blobs.org

      Killer T cells animation from Raven. Not very helpful.

      Antibodies and allergic reactions from Raven. Although about hypersensitivity, thi= s is also a very good animation of the specific immune response. Good introducti= on.

      Specific Immunity fr= om North Harris College. Odd animat= ions. Not very helpful.

      Antigen Processing

      Immune response from madder (lots!)

      Cytoxic T-cells animation1 from McKinley

      Cytoxic T-cell animation 2 from McKinley

Overviews

Vacc= ination

      Making vaccines from Madder

      Vaccine Strategi= es from Kuby

      M= MR the facts from the NHS

Written by Neil C Millar, Heckmondwike Grammar School. nmillar@heckgrammar.ki= rlklees.sch.uk. Last updated May 2007.